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Journal of Biomedical Optics • Open Access

Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy
Author(s): Leilei Zhang; Jeff S. Xu; Virgil E. Sanders; Alan D. Letson; Cynthia J. Roberts; Ronald X. Xu

Paper Abstract

We synthesize multifunctional microbubbles (MBs) for targeted delivery of antivascular endothelial growth factor (antiVEGF) therapy with multimodal imaging guidance. Poly-lactic-co-glycolic acid (PLGA) MBs encapsulating Texas Red dye are fabricated by a modified double-emulsion process. Simultaneous ultrasound and fluorescence imaging are achieved using Texas Red encapsulated MBs. The MBs are conjugated with Avastin, an antiVEGF antibody for treating neovascular age-related macular degeneration (AMD). The conjugation efficiency is characterized by enzyme-linked immunosorbent assay (ELISA). The efficiency for targeted binding of Avastin-conjugated MBs is characterized by microscopic imaging. Our work demonstrates the technical potential of using multifunctional MBs for targeted delivery of antiVEGF therapy in the treatment of exudative AMD.

Paper Details

Date Published: 1 May 2010
PDF: 3 pages
J. Biomed. Opt. 15(3) 030515 doi: 10.1117/1.3457669
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Leilei Zhang, The Ohio State Univ. (United States)
Jeff S. Xu, The Ohio State Univ. (United States)
Virgil E. Sanders, Los Alamos National Lab. (United States)
Alan D. Letson, The Ohio State Univ. (United States)
Cynthia J. Roberts, The Ohio State Univ. (United States)
Ronald X. Xu, The Ohio State Univ. (United States)


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