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Journal of Biomedical Optics • Open Access

Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1600 nm

Paper Abstract

We demonstrate a method to estimate the concentrations of water and lipid in scattering media such as biological tissues with diffuse optical spectra acquired over the range of 900 to 1600 nm. Estimations were performed by fitting the spectra to a model of light propagation in scattering media derived from diffusion theory. To validate the method, spectra were acquired from tissue phantoms consisting of lipid and water emulsions and swine tissues ex vivo with a two-fiber probe.

Paper Details

Date Published: 1 May 2010
PDF: 10 pages
J. Biomed. Opt. 15(3) 037015 doi: 10.1117/1.3454392
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Rami Nachabe, Philips Research Nederland B.V. (Netherlands)
Benno H. W. Hendriks, Philips Research Nederland B.V. (Netherlands)
Adrien E. Desjardins, Philips Research Nederland B.V. (Netherlands)
Marjolein van der Voort, Philips Research Nederland B.V. (Netherlands)
Martin B. van der Mark, Philips Research Nederland B.V. (Netherlands)
Henricus J. C. M. Sterenborg, Erasmus MC (Netherlands)

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