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Journal of Biomedical Optics

In vivo carotid artery closure by laser activation of hyaluronan-embedded gold nanorods
Author(s): Paolo Matteini; Fulvio Ratto; Francesca Rossi; Giacomo Rossi; Giuseppe Esposito; Alfredo Puca; Alessio Albanese; Giulio Maira; Roberto Pini
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Paper Abstract

We prove the first application of near-infrared-absorbing gold nanorods (GNRs) for in vivo laser closure of a rabbit carotid artery. GNRs are first functionalized with a biopolymeric shell and then embedded in hyaluronan, which gives a stabilized and handy laser-activable formulation. Four rabbits undergo closure of a 3-mm longitudinal incision performed on the carotid artery by means of a 810-nm diode laser in conjunction with the topical application of the GNRs composite. An effective surgery is obtained by using a 40-W/cm2 laser power density. The histological and electron microscopy evaluation after a 30-day follow-up demonstrates complete healing of the treated arteries with full re-endothelization at the site of GNRs application. The absence of microgranuloma formation and/or dystrophic calcification is evidence that no host reaction to nanoparticles interspersed through the vascular tissue occurred. The observation of a reshaping and associated blue shift of the NIR absorption band of GNRs after laser treatment supports the occurrence of a self-terminating process, and thus of additional safety of the minimally invasive laser procedure. This study underlines the feasibility of using GNRs for in vivo laser soldering applications, which represents a step forward toward the introduction of nanotechnology-based therapies in minimally invasive clinical practices.

Paper Details

Date Published: 1 July 2010
PDF: 6 pages
J. Biomed. Opt. 15(4) 041508 doi: 10.1117/1.3449574
Published in: Journal of Biomedical Optics Volume 15, Issue 4
Show Author Affiliations
Paolo Matteini, Istituto di Fisica Applicata Nello Carrara (Italy)
Fulvio Ratto, Istituto di Fisica Applicata Nello Carrara (Italy)
Francesca Rossi, Istituto di Fisica Applicata Nello Carrara (Italy)
Giacomo Rossi, Univ. degli Studi di Camerino (Italy)
Giuseppe Esposito, Georgetown Univ. Medical Ctr. (United States)
Alfredo Puca, Univ. Cattolica del Sacro Cuore (Italy)
Alessio Albanese, Univ. Cattolica del Sacro Cuore (Italy)
Giulio Maira, Univ. Cattolica del Sacro Cuore (Italy)
Roberto Pini, Istituto di Fisica Applicata Nello Carrara (Italy)


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