Share Email Print

Journal of Biomedical Optics • Open Access

In-vitro retinal model reveals a sharp transition between laser damage mechanisms
Author(s): Michael L. Denton; Clifton D. Clark; Michael S. Foltz; Kurt J. Schuster; Gary D. Noojin; Larry E. Estlack; Robert J. Thomas

Paper Abstract

We use laser damage thresholds in an in-vitro retinal model, and computational simulations to examine the laser exposure durations at which damage transitions from photothermal to photochemical at 413 nm. Our results indicate a dramatic shift in 1-h damage thresholds between exposure durations of 60 and 100 s. The trend in our in-vitro results is similar to a trend found in a recent study where retinal lesions were assessed 1-h post laser exposure in the rhesus eye Our data suggest that nonthermal mechanisms did not significantly contribute to cell death, even for exposures of 60 s. Knowledge of the transition point, and lack of concurrent thermal and nonthermal damage processes, are significant for those wishing to devise a comprehensive computational damage model.

Paper Details

Date Published: 1 May 2010
PDF: 3 pages
J. Biomed. Opt. 15(3) 030512 doi: 10.1117/1.3449107
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Michael L. Denton, Northrop Grumman Mission Systems (United States)
Clifton D. Clark, Northrop Grumman Mission Systems (United States)
Michael S. Foltz, Northrop Grumman Mission Systems (United States)
Kurt J. Schuster, Northrop Grumman Mission Systems (United States)
Gary D. Noojin, Northrop Grumman Mission Systems (United States)
Larry E. Estlack, Conceptual MindWorks, Inc. (United States)
Robert J. Thomas, Air Force Research Lab. (United States)

© SPIE. Terms of Use
Back to Top