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Journal of Biomedical Optics • Open Access

Imaging port wine stains by fiber optical coherence tomography
Author(s): Shiyong Zhao; Ying Gu; Ping Xue; Jin Guo; Tingmei Shen; Tianshi Wang; Naiyan Huang; Li Zhang; Haixia Qiu; Yu Xin; Xunbin Wei

Paper Abstract

We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). We use our OCT system on 41 patients with PWS to document the difference between PWS skin and contralateral normal skin. The system, which operates at 4 frames/s with axial and transverse resolutions of 10 and 9 µm, respectively, in the skin tissue, can clearly distinguish the dilated dermal blood vessels from normal tissue. We present OCT images of patients with PWS and normal human skin. We obtain the structural parameters, including epidermal thickness and diameter and depth of dilated blood vessels. We demonstrate that OCT may be a useful tool for the noninvasive imaging of PWS. It may help determine the photosensitizer dose and laser parameters in photodynamic therapy for treating port wine stains.

Paper Details

Date Published: 1 May 2010
PDF: 6 pages
J. Biomed. Opt. 15(3) 036020 doi: 10.1117/1.3445712
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Shiyong Zhao, Beijing Institute of Technology (China)
Ying Gu, Chinese PLA General Hospital (China)
Ping Xue, Tsinghua Univ. (China)
Jin Guo, Fudan Univ. (China)
Tingmei Shen, Beijing Institute of Technology (China)
Tianshi Wang, Tsinghua Univ. (China)
Naiyan Huang, The BC Cancer Agency Research Ctr. (Canada)
Li Zhang, Fudan Univ. (China)
Haixia Qiu, Chinese PLA General Hospital (China)
Yu Xin, Beijing Institute of Technology (China)
Xunbin Wei, Fudan Univ. (China)

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