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Journal of Biomedical Optics

Identification of abnormal motor cortex activation patterns in children with cerebral palsy by functional near-infrared spectroscopy
Author(s): Bilal Khan; Fenghua Tian; Khosrow Behbehani; Mario Romero-Ortega; Mauricio R. Delgado; Nancy Clegg; Linsley Smith; Dahlia Reid; Hanli Liu; George Alexandrakis
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Paper Abstract

We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4±2.3 years old in both groups) performing a finger-tapping protocol. Spatial (distance from center and area difference) and temporal (duration and time-to-peak) image metrics are proposed as potential biomarkers for differentiating abnormal cortical activation in children with CP from healthy pediatric controls. In addition, a similarity image-analysis concept is presented that unveils areas that have similar activation patterns as that of the maximum activation area, but are not discernible by visual inspection of standard activation images. Metrics derived from the images presenting areas of similarity are shown to be sensitive identifiers of abnormal activation patterns in children with CP. Importantly, the proposed similarity concept and related metrics may be applicable to other studies for the identification of cortical activation patterns by fNIRS.

Paper Details

Date Published: 1 May 2010
PDF: 14 pages
J. Biomed. Opt. 15(3) 036008 doi: 10.1117/1.3432746
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Bilal Khan, The Univ. of Texas at Arlington (United States)
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Khosrow Behbehani, The Univ. of Texas at Arlington (United States)
Mario Romero-Ortega, The Univ. of Texas at Arlington (United States)
Mauricio R. Delgado, Texas Scottish Rite Hospital for Children (United States)
Nancy Clegg, Texas Scottish Rite Hospital for Children (United States)
Linsley Smith, Texas Scottish Rite Hospital for Children (United States)
Dahlia Reid, Texas Scottish Rite Hospital for Children (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)
George Alexandrakis, The Univ. of Texas at Arlington (United States)


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