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Journal of Biomedical Optics

Near-infrared imaging of the sinuses: preliminary evaluation of a new technology for diagnosing maxillary sinusitis
Author(s): Usama Mahmood; Albert E. Cerussi; Reza Dehdari; Quoc Nguyen; Timothy Kelley; Bruce Jason Tromberg; Brian Jet-Fei Wong
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Paper Abstract

Diagnosing sinusitis remains a challenge for primary care physicians. There is a need for a simple, office-based technique to aid in the diagnosis of sinusitis without the cost and radiation risk of conventional radiologic imaging. We designed a low-cost near-infrared (NIR) device to transilluminate the maxillary sinuses. The use of NIR light allows for greater interrogation of deep-tissue structures as compared to visible light. NIR imaging of 21 patients was performed and compared with computed tomography (CT) scans. Individual maxillary sinuses were scored on a scale from 0 to 2 based on their degree of aeration present on CT and similarly based on the NIR signal penetration into the maxilla on NIR images. Our results showed that air-filled and fluid/tissue-filled spaces can be reasonably distinguished by their differing NIR signal penetration patterns, with average NIR imaging scores for fluid-filled maxillary sinuses (0.93±0.78, n=29) significantly lower than those for normal maxillary sinuses (1.62±0.57, n=13) (p=0.003). NIR imaging of the sinuses is a simple, safe, and cost-effective modality that can potentially aid in the diagnosis of sinusitis. Long-term, significant device refinement and large clinical trials will be needed to determine the diagnostic accuracy of this technique.

Paper Details

Date Published: 1 May 2010
PDF: 5 pages
J. Biomed. Opt. 15(3) 036011 doi: 10.1117/1.3431718
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Usama Mahmood, Univ. of California, Irvine (United States)
Albert E. Cerussi, Beckman Laser Institute and Medical Clinic (United States)
Reza Dehdari, Univ. of California, Irvine (United States)
Quoc Nguyen, Univ. of California, Irvine (United States)
Timothy Kelley, Univ. of California, Irvine (United States)
Bruce Jason Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Brian Jet-Fei Wong, Beckman Laser Institute and Medical Clinic (United States)


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