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Journal of Biomedical Optics

Inspired gas-induced vascular change in tumors with magnetic-resonance-guided near-infrared imaging: human breast pilot study
Author(s): Colin M. Carpenter; Rebecca Rakow-Penner; Shudong Jiang; Bruce L. Daniel; Brian W. Pogue; Gary H. Glover; Keith D. Paulsen
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Paper Abstract

This study investigates differences in the response of breast tumor tissue versus healthy fibroglandular tissue to inspired gases. Cycles of carbogen and oxygen gas are administered while measuring the changes with magnetic-resonance-guided near-infrared imaging in a pilot study of breast cancers. For two patients, analyses are performed with cross-correlation techniques, which measure the strength of hemodynamic modulation. The results show that the overall vasoresponse, indicated by total hemoglobin, of healthy tissue has approximately a 72% and 41% greater correlation to the gas stimulus than the tumor region, in two patients respectively, when background physiological changes are controlled. These data support the hypothesis that tumor vasculature has a poorly functioning vasodilatory mechanism, most likely caused by dysfunctional smooth muscle cells lining the vasculature. This study presents a methodology to quantitatively analyze inspired gas changes in human breast tumors, and demonstrates this technique in a pilot patient population.

Paper Details

Date Published: 1 May 2010
PDF: 5 pages
J. Biomed. Opt. 15(3) 036026 doi: 10.1117/1.3430729
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Colin M. Carpenter, Dartmouth College (United States)
Rebecca Rakow-Penner
Shudong Jiang, Dartmouth College (United States)
Bruce L. Daniel, Stanford Univ. School of Medicine (United States)
Brian W. Pogue, Dartmouth College (United States)
Gary H. Glover, Stanford Univ. (United States)
Keith D. Paulsen, Dartmouth College (United States)


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