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Journal of Biomedical Optics • Open Access

Change in spectrum of Brownian fluctuations of optically trapped red blood cells due to malarial infection
Author(s): Vishal Saraogi; P. Padmapriya; Apurba Paul; Utpal S. Tatu; Vasant Natarajan

Paper Abstract

We study the properties of single red blood cells (RBCs) held in an optical-tweezers trap. We observe a change in the spectrum of Brownian fluctuations between RBCs from normal and malaria-infected samples. The change, caused by infection-induced structural changes in the cell, appears as a statistical increase in the mean (by 25%) and standard deviation (by 200%) of the corner frequency measured over ~100 cells. The increase is observed even though the ensemble of cells being measured consists mostly of cells that do not actually host the parasite, but are from an infected pool. This bystander effect appears to vindicate other observations that infected cells can affect the biomechanical properties of uninfected cells. The change is also observed to be independent of the stage of infection and its duration, highlighting its potential for disease detection.

Paper Details

Date Published: 1 May 2010
PDF: 5 pages
J. Biomed. Opt. 15(3) 037003 doi: 10.1117/1.3427142
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Vishal Saraogi, Indian Institute of Science (India)
P. Padmapriya, Indian Institute of Science (India)
Apurba Paul, Indian Institute of Science (India)
Utpal S. Tatu, Indian Institute of Science (India)
Vasant Natarajan, Indian Institute of Science (India)

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