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Journal of Biomedical Optics • Open Access

Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects
Author(s): Turgut Durduran; Chao Zhou; Erin M. Buckley; Meeri N. Kim; Guoqiang Yu; Regine Choe; J. William Gaynor; Thomas L. Spray; Suzanne M. Durning; Stefanie E. Mason; Lisa M. Montenegro; Susan C. Nicolson; Robert A. Zimmerman; Mary E. Putt; Jiongjiong Wang; Joel H. Greenberg; John A. Detre; Arjun G. Yodh; Daniel J. Licht

Paper Abstract

We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBFASL-MRI, n=12) cross-validate rCBFDCS against rCBFASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.

Paper Details

Date Published: 1 May 2010
PDF: 10 pages
J. Biomed. Opt. 15(3) 037004 doi: 10.1117/1.3425884
Published in: Journal of Biomedical Optics Volume 15, Issue 3
Show Author Affiliations
Turgut Durduran, ICFO - Instituto de Ciencias Fotónicas (Spain)
Chao Zhou, Univ. of Pennsylvania (United States)
Erin M. Buckley, Univ. of Pennsylvania (United States)
Meeri N. Kim, Univ. of Pennsylvania (United States)
Guoqiang Yu, Univ. of Kentucky (United States)
Regine Choe, Univ. of Pennsylvania (United States)
J. William Gaynor, Univ. of Kentucky (United States)
Thomas L. Spray, Univ. of Kentucky (United States)
Suzanne M. Durning, Univ. of Pennsylvania (United States)
Stefanie E. Mason, Univ. of Kentucky (United States)
Lisa M. Montenegro, The Children's Hospital of Philadelphia (United States)
Susan C. Nicolson, The Children's Hospital of Philadelphia (United States)
Robert A. Zimmerman, The Children's Hospital of Philadelphia (United States)
Mary E. Putt, The Univ. of Pennsylvania Health System (United States)
Jiongjiong Wang, The Univ. of Pennsylvania Health System (United States)
Joel H. Greenberg, The Univ. of Pennsylvania Health System (United States)
John A. Detre, The Univ. of Pennsylvania Health System (United States)
Arjun G. Yodh, Univ. of Pennsylvania (United States)
Daniel J. Licht, The Children's Hospital of Philadelphia (United States)


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