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Journal of Biomedical Optics • Open Access

Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
Author(s): YongKeun Park; Monica Diez-Silva; Dan Fu; Gabriel Popescu; Wonshik Choi; Ishan Barman; Subra Suresh; Michael S. Feld

Paper Abstract

We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.

Paper Details

Date Published: 1 March 2010
PDF: 3 pages
J. Biomed. Opt. 15(2) 020506 doi: 10.1117/1.3369966
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
YongKeun Park, Massachusetts Institute of Technology (United States)
Monica Diez-Silva, Massachusetts Institute of Technology (United States)
Dan Fu, Massachusetts Institute of Technology (United States)
Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)
Wonshik Choi, Korea Univ. (Korea, Republic of)
Ishan Barman, Massachusetts Institute of Technology (United States)
Subra Suresh, Massachusetts Institute of Technology (United States)
Michael S. Feld, Massachusetts Institute of Technology (United States)


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