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Journal of Biomedical Optics

Blood screening using diffraction phase cytometry
Author(s): Mustafa Mir; Huafeng Ding; Zhuo Wang; Krishnarao Tangella; Gabriel Popescu
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Paper Abstract

advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detailed morphology of individual cells, and merely alert the operator to manually examine a blood smear by raising flags when abnormalities are detected. We demonstrate an automatic interferometry-based smear analysis technique known as diffraction phase cytometry (DPC), which is capable of providing the same information on red blood cells as is provided by current clinical analyzers, while rendering additional, currently unavailable parameters on the 2-D and 3-D morphology of individual red blood cells. To validate the utility of our technique in a clinical setting, we present a comparison between tests generated from 32 patients by a state of the art clinical impedance counter and DPC.

Paper Details

Date Published: 1 March 2010
PDF: 4 pages
J. Biomed. Opt. 15(2) 027016 doi: 10.1117/1.3369965
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Mustafa Mir, Univ. of Illinois at Urbana-Champaign (United States)
Huafeng Ding, Univ. of Illinois at Urbana-Champaign (United States)
Zhuo Wang, Univ. of Illinois at Urbana-Champaign (United States)
Krishnarao Tangella, Univ. of Illinois at Urbana-Champaign (United States)
Gabriel Popescu, Univ. of Illinois at Urbana-Champaign (United States)

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