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Journal of Biomedical Optics

Quantitative analysis of creatinine in urine by metalized nanostructured parylene
Author(s): Hui Wang; Niranjan Malvadkar; S. Koytek; J. Bylander; W. Brian Reeves; Melik C. Demirel
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Paper Abstract

A highly accurate, real-time multisensor agent monitor for biomarker detection is required for early detection of kidney diseases. Urine creatinine level can provide useful information on the status of the kidney. We prepare nanostructured surface-enhanced Raman spectroscopy (SERS) substrates without template or lithography, which provides controllable, well-organized nanostructures on the surface, for the quantitative analysis of creatinine concentration in urine. We present our work on sensitivity of the SERS substrate to urine samples collected from diabetic patients and healthy persons. We report the preparation of a new type of SERS substrate, which provides fast (<10 s), highly sensitive (creatinine concentration <0.5 μg/mL) and reproducible (<5% variation) detection of urine. Our method to analyze the creatinine level in urine is in good agreement with the enzymatic method.

Paper Details

Date Published: 1 March 2010
PDF: 5 pages
J. Biomed. Opt. 15(2) 027004 doi: 10.1117/1.3369002
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Hui Wang, The Pennsylvania State Univ. (United States)
Niranjan Malvadkar, The Pennsylvania State Univ. (United States)
S. Koytek, The Pennsylvania State Univ. (United States)
J. Bylander, The Pennsylvania State Univ. (United States)
W. Brian Reeves, The Pennsylvania State Univ. (United States)
Melik C. Demirel, The Pennsylvania State Univ. (United States)


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