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Journal of Biomedical Optics • Open Access

Gold nanorods for fluorescence lifetime imaging in biology
Author(s): Yinan Zhang; Jun Yu; David J. S. Birch; Yu Chen

Paper Abstract

Two-photon luminescence (TPL) from gold nanorods shows considerable potential in biological imaging. We study the imaging of gold nanorods in Madin-Darby canine kidney (MDCK) cells using fluorescence lifetime imaging microscopy (FLIM). FLIM provides images with better contrast and sensitivity than intensity imaging. The characteristic fluorescence lifetime of gold nanorods is found to be less than 100 ps, which can be used to distinguish gold nanorods from other fluorescent labels and endogenous fluorophores in lifetime imaging.

Paper Details

Date Published: 1 March 2010
PDF: 3 pages
J. Biomed. Opt. 15(2) 020504 doi: 10.1117/1.3366646
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Yinan Zhang, Univ. of Strathclyde (United Kingdom)
Jun Yu, Univ. of Strathclyde (United Kingdom)
David J. S. Birch, Univ. of Strathclyde (United Kingdom)
Yu Chen, Univ. of Strathclyde (United Kingdom)


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