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Journal of Micro/Nanolithography, MEMS, and MOEMS

Prevention of nonspecific adsorption onto a poly(dimethylsiloxane) microchannel in a microsensor chip by using a self-assembled monolayer
Author(s): Toshikazu Kawaguchi; Hiroyuki Iwasaka; Kiyoshi Matsumoto; Kiyoshi Toko; Norio Miura
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Paper Abstract

Poly (dimethylsiloxane) (PDMS) is meant to be utilized for a miniaturized sensor system. However, protein and biospecies often adsorb onto a PDMS surface nonspecifically. This matter is a serious challenge in the study of miniaturized sensor systems. We provide the solution, which is a prevention technique of nonspecific adsorption onto a PDMS microchip by using a functionalized silane compound self-assembled monolayer. Two demonstrations for bacteria and explosives were examined by atomic force microscopy and x-ray photoelectron spectroscopy. It was found that 1H, 1H, 2H, 2H-Perfluorooctyltriethoxysilane self-assembled monolayer on PDMS effectively blocked the nonspecific adsorption of Escherichia coli (O157:H7) and explosives such as 2, 4, 6-trinitrotoluene and 1, 3, 5-trinitroperhydro-1,3,5-triazine (RDX, Research Department Explosive).

Paper Details

Date Published: 1 January 2010
PDF: 5 pages
J. Micro/Nanolith. 9(1) 013012 doi: 10.1117/1.3366559
Published in: Journal of Micro/Nanolithography, MEMS, and MOEMS Volume 9, Issue 1
Show Author Affiliations
Toshikazu Kawaguchi, Kyushu Univ. (Japan)
Hiroyuki Iwasaka, OMRON Corp. (Japan)
Kiyoshi Matsumoto, Kyushu Univ. (Japan)
Kiyoshi Toko, Kyushu Univ. (Japan)
Norio Miura, Kyushu Univ. (Japan)

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