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Journal of Biomedical Optics

Second-harmonic generation imaging of collagen fibers in myocardium for atrial fibrillation diagnosis
Author(s): Ming-Rung Tsai; Yu-Wei Chiu; Men Tzung Lo; Chi-Kuang Sun
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Paper Abstract

Atrial fibrillation (AF) is the most common irregular heart rhythm and the mortality rate for patients with AF is approximately twice the mortality rate for patients with normal sinus rhythm (NSR). Some research has indicated that myocardial fibrosis plays an important role in predisposing patients to AF. Therefore, realizing the relationship between myocardial collagen fibrosis and AF is significant. Second-harmonic generation (SHG) is an optically nonlinear coherent process to image the collagen network. We perform SHG microscopic imaging of the collagen fibers in the human atrial myocardium. Utilizing the SHG images, we can identify the differences in morphology and the arrangement of collagen fibers between NSR and AF tissues. We also quantify the arrangement of the collagen fibers using Fourier transform images and calculating the values of angle entropy. We indicate that SHG imaging, a nondestructive and reproducible method to analyze the arrangement of collagen fibers, can provide explicit information about the relationship between myocardial fibrosis and AF.

Paper Details

Date Published: 1 March 2010
PDF: 6 pages
J. Biomed. Opt. 15(2) 026002 doi: 10.1117/1.3365943
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Ming-Rung Tsai, National Taiwan Univ. (Taiwan)
Yu-Wei Chiu, Far Eastern Memorial Hospital (Taiwan)
Men Tzung Lo, National Central Univ. (Taiwan)
Chi-Kuang Sun, National Taiwan Univ. (Taiwan)

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