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Journal of Biomedical Optics

Silver nanosystems for photoacoustic imaging and image-guided therapy
Author(s): Kimberly A. Homan; Jignesh Shah; Sobeyda Gomez; Heidi Gensler; Andrei B. Karpiouk; Lisa Brannon-Peppas; Stanislav Y. Emelianov
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Paper Abstract

Due to their optical absorption properties, metallic nanoparticles are excellent photoacoustic imaging contrast agents. A silver nanosystem is presented here as a potential contrast agent for photoacoustic imaging and image-guided therapy. Currently, the nanosystem consists of a porous silver layer deposited on the surface of spherical silica cores ranging in diameter from 180 to 520 nm. The porous nature of the silver layer will allow for release of drugs or other therapeutic agents encapsulated in the core in future applications. In their current PEGylated form, the silver nanosystem is shown to be nontoxic in vitro at concentrations of silver up to 2 mg/ml. Furthermore, the near-infrared absorbance properties of the nanosystem are demonstrated by measuring strong, concentration-dependent photoacoustic signal from the silver nanosystem embedded in an ex vivo tissue sample. Our study suggests that silver nanosystems can be used as multifunctional agents capable of augmenting image-guided therapy techniques.

Paper Details

Date Published: 1 March 2010
PDF: 9 pages
J. Biomed. Opt. 15(2) 021316 doi: 10.1117/1.3365937
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Kimberly A. Homan, The Univ. of Texas at Austin (United States)
Jignesh Shah, Volcano Corp. (United States)
Sobeyda Gomez, The Univ. of Texas at Austin (United States)
Heidi Gensler, Univ. of California, Los Angeles (United States)
Andrei B. Karpiouk, The Univ. of Texas at Austin (United States)
Lisa Brannon-Peppas, The Univ. of Texas at Austin (United States)
Stanislav Y. Emelianov, The Univ. of Texas at Austin (United States)

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