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Journal of Biomedical Optics

Saturation effect in functional photoacoustic imaging
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Paper Abstract

We investigate the saturation effect, which describes the violation of the linearity between the measured photoacoustic amplitude and the object's optical absorption coefficient in functional photoacoustic imaging when the optical absorption in the object increases. We model the optical energy deposition and photoacoustic signal generation and detection in a semi-infinite optical absorbing object. Experiments are carried out by measuring photoacoustic signals generated from an ink-filled plastic tube. The saturation effect is studied by varying the optical absorption coefficient in the model and the ink concentration in the photoacoustic experiments. By changing the center frequency of the ultrasonic detector, the requirement to minimize the saturation effect in functional photoacoustic imaging is established.

Paper Details

Date Published: 1 March 2010
PDF: 5 pages
J. Biomed. Opt. 15(2) 021317 doi: 10.1117/1.3333549
Published in: Journal of Biomedical Optics Volume 15, Issue 2
Show Author Affiliations
Jing Wang, Univ. of Wisconsin-Milwaukee (United States)
Tan Liu, Univ. of Wisconsin-Milwaukee (United States)
Shuliang Jiao, The Univ. of Southern California (United States)
Ruimin Chen, The Univ. of Southern California (United States)
Qifa Zhou, The Univ. of Southern California (United States)
K. Kirk Shung, The Univ. of Southern California (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Hao F. Zhang, Univ. of Wisconsin-Milwaukee (United States)


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