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Journal of Biomedical Optics

Fluorescence lifetime in cardiovascular diagnostics
Author(s): Laura Marcu
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Paper Abstract

We review fluorescence lifetime techniques including time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.

Paper Details

Date Published: 1 January 2010
PDF: 10 pages
J. Biomed. Opt. 15(1) 011106 doi: 10.1117/1.3327279
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Laura Marcu, Univ. of California, Davis (United States)


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