Share Email Print

Journal of Nanophotonics

Numerical simulation of near-field fluorescence correlation spectroscopy using a fiber probe
Author(s): Kazuo Kasahara; Toshiharu Saiki
Format Member Price Non-Member Price
PDF $20.00 $25.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Numerical simulation of fluorescence correlation spectroscopy (FCS) based on near-field scanning optical microscopy (NSOM) was performed. A finite-difference time-domain method was employed to calculate the electric field distribution in the vicinity of the NSOM aperture and the Brownian motion of nanoparticles was reproduced by a Monte Carlo simulation. The physical validity of the simulation result was confirmed by comparing it with a theoretical calculation using a Gaussian observation volume, which is applied to FCS based on conventional optical microscopy.

Paper Details

Date Published: 1 January 2010
PDF: 6 pages
J. Nanophoton. 4(1) 043502 doi: 10.1117/1.3319569
Published in: Journal of Nanophotonics Volume 4, Issue 1
Show Author Affiliations
Kazuo Kasahara, Keio Univ. (Japan)
Toshiharu Saiki, Keio Univ. (Japan)

© SPIE. Terms of Use
Back to Top