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Journal of Nanophotonics

Numerical simulation of near-field fluorescence correlation spectroscopy using a fiber probe
Author(s): Kazuo Kasahara; Toshiharu Saiki
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Paper Abstract

Numerical simulation of fluorescence correlation spectroscopy (FCS) based on near-field scanning optical microscopy (NSOM) was performed. A finite-difference time-domain method was employed to calculate the electric field distribution in the vicinity of the NSOM aperture and the Brownian motion of nanoparticles was reproduced by a Monte Carlo simulation. The physical validity of the simulation result was confirmed by comparing it with a theoretical calculation using a Gaussian observation volume, which is applied to FCS based on conventional optical microscopy.

Paper Details

Date Published: 1 January 2010
PDF: 6 pages
J. Nanophoton. 4(1) 043502 doi: 10.1117/1.3319569
Published in: Journal of Nanophotonics Volume 4, Issue 1
Show Author Affiliations
Kazuo Kasahara, Keio Univ. (Japan)
Toshiharu Saiki, Keio Univ. (Japan)

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