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Journal of Biomedical Optics • Open Access

Detection of vesicant-induced upper airway mucosa damage in the hamster cheek pouch model using optical coherence tomography
Author(s): Marie J. Hammer-Wilson; Vi Nguyen; Woonggyu Jung; Yeh-Chan Ahn; Zhongping Chen; Petra B. B. Wilder-Smith

Paper Abstract

Hamster cheek pouches were exposed to 2-chloroethyl ethyl sulfide [CEES, half-mustard gas (HMG)] at a concentration of 0.4, 2.0, or 5.0 mg/ml for 1 or 5 min. Twenty-four hours post-HMG exposure, tissue damage was assessed by both stereomicrography and optical coherence tomography (OCT). Damage that was not visible on gross visual examination was apparent in the OCT images. Tissue changes were found to be dependent on both HMG concentration and exposure time. The submucosal and muscle layers of the cheek pouch tissue showed the greatest amount of structural alteration. Routine light microscope histology was performed to confirm the OCT observations.

Paper Details

Date Published: 1 January 2010
PDF: 5 pages
J. Biomed. Opt. 15(1) 016017 doi: 10.1117/1.3309455
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Marie J. Hammer-Wilson, Beckman Laser Institute and Medical Clinic (United States)
Vi Nguyen, Beckman Laser Institute and Medical Clinic (United States)
Woonggyu Jung, Univ. of Illinois at Urbana-Champaign (United States)
Yeh-Chan Ahn, Beckman Laser Institute and Medical Clinic (United States)
Zhongping Chen, Beckman Laser Institute and Medical Clinic (United States)
Petra B. B. Wilder-Smith, Beckman Laser Institute and Medical Clinic (United States)


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