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Journal of Biomedical Optics

Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid medium
Author(s): Nrusingh C. Biswal; John K. Gamelin; Baohong Yuan; Marina V. Backer; Joseph M. Backer; Quing Zhu
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Paper Abstract

We demonstrate the feasibility of fluorescence imaging of deeply seated tumors using mice injected with an angiogenesis tracer, a vascular endothelial growth factor conjugated with the infrared dye cyanine 7 (VEGF/Cy7). Our optical-only imaging reconstruction method separately estimates the target depth, and then applies this information to reconstruct functional information such as fluorophore concentration. Fluorescence targets with concentrations as low as sub-25 nM are well reconstructed at depths up to 2 cm in both homogeneous and heterogeneous media with this technique.

Paper Details

Date Published: 1 January 2010
PDF: 11 pages
J. Biomed. Opt. 15(1) 016012 doi: 10.1117/1.3306704
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Nrusingh C. Biswal, Univ. of Connecticut (United States)
John K. Gamelin, CAS Medical Systems, Inc. (United States)
Baohong Yuan, The Catholic Univ. of America (United States)
Marina V. Backer, SibTech, Inc. (United States)
Joseph M. Backer, SibTech, Inc. (United States)
Quing Zhu, Univ. of Connecticut (United States)

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