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Journal of Biomedical Optics • Open Access

Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

Paper Abstract

We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

Paper Details

Date Published: 1 January 2010
PDF: 3 pages
J. Biomed. Opt. 15(1) 010510 doi: 10.1117/1.3302808
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Chulhong Kim, Washington Univ. in St. Louis (United States)
Ruogu Qin, The Ohio State Univ. (United States)
Jeff S. Xu, The Ohio State Univ. (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)
Ronald X. Xu, The Ohio State Univ. (United States)

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