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Journal of Biomedical Optics • Open Access

Real-time photoacoustic tomography of cortical hemodynamics in small animals

Paper Abstract

For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.

Paper Details

Date Published: 1 January 2010
PDF: 3 pages
J. Biomed. Opt. 15(1) 010509 doi: 10.1117/1.3302807
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Changhui Li, Washington Univ. in St. Louis (United States)
Andres Aguirre, Univ. of Connecticut (United States)
John K. Gamelin, CAS Medical Systems, Inc. (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)

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