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Journal of Biomedical Optics • Open Access

Relative capacities of time-gated versus continuous-wave imaging to localize tissue embedded vessels with increasing depth

Paper Abstract

Surgeons often cannot see major vessels embedded in adipose tissue and inadvertently injure them. One such example occurs during surgical removal of the gallbladder, where injury of the nearby common bile duct leads to life-threatening complications. Near-infrared imaging of the intraoperative field may help surgeons localize such critical tissue-embedded vessels. We have investigated how continuous-wave (CW) imaging performs relative to time-gated wide-field imaging, presently a rather costly technology, under broad Gaussian beam-illumination conditions. We have studied the simplified case of an isolated cylinder having bile-duct optical properties, embedded at different depths within a 2-cm slab of adipose tissue. Monte Carlo simulations were preformed for both reflectance and transillumination geometries. The relative performance of CW versus time-gated imaging was compared in terms of spatial resolution and contrast-to-background ratio in the resulting simulated images. It was found that time-gated imaging offers superior spatial resolution and vessel-detection sensitivity in most cases, though CW transillumination measurements may also offer satisfactory performance for this tissue geometry at lower cost. Experiments were performed in reflectance geometry to validate simulation results, and potential challenges in the translation of this technology to the clinic are discussed.

Paper Details

Date Published: 1 January 2010
PDF: 9 pages
J. Biomed. Opt. 15(1) 016015 doi: 10.1117/1.3299728
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Nimit L. Patel, The Univ. of Texas at Arlington (United States)
Zi-Jing Lin, The Univ. of Texas at Arlington (United States)
Yajuvendra Rathore, The Univ. of Texas at Arlington (United States)
Edward Livingston, The Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)
George Alexandrakis, The Univ. of Texas at Arlington (United States)

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