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Journal of Biomedical Optics • Open Access

Enhanced photoacoustic stability of gold nanorods by silica matrix confinement
Author(s): Leng-Chun Chen; Chen-Wei Wei; Jeffrey S. Souris; Shih-Hsun Cheng; Chin-Tu Chen; Chung-Shi Yang; Pai-Chi Li; Leu-Wei Lo

Paper Abstract

Photoacoustic tomography (PAT) has garnered much attention for its high contrast and excellent spatial resolution of perfused tissues. Gold nanorods (GNRs) have been employed to further enhance the imaging contrast of PAT. However, the photon fluences typically needed for PA wave induction often also result in GNR shape changes that significantly reduce the efficiency of acoustic wave generation. In this work, we propose, synthesize, and evaluate amorphous silica-coated gold nanorods (GNR-Si) in an effort to improve contrast agent stability and ameliorate efficiency loss during photoacoustic (PA) wave induction. TEM and optical absorption spectra measurements of GNR and GNR-Si show that encasing GNRs within amorphous silica provides substantial protection of nanorod conformation from thermal deformation. PA signals generated by GNR-Si demonstrate considerably greater resistance to degradation of signal intensity with repetitive pulsing than do uncoated GNRs, thereby enabling much longer, high-contrast imaging sessions than previously possible. The prolongation of high-contrast imaging, and biocompatibility and easy surface functionalization for targeting ligands afforded by amorphous silica, suggest GNR-Si to be potentially significant for the clinical translation of PAT.

Paper Details

Date Published: 1 January 2010
PDF: 6 pages
J. Biomed. Opt. 15(1) 016010 doi: 10.1117/1.3292574
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Leng-Chun Chen, National Health Research Institutes (Taiwan)
Chen-Wei Wei, National Taiwan Univ. (Taiwan)
Jeffrey S. Souris, The Univ. of Chicago Medical Ctr. (United States)
Shih-Hsun Cheng, National Health Research Institutes (Taiwan)
Chin-Tu Chen, The Univ. of Chicago Medical Ctr. (United States)
Chung-Shi Yang, National Health Research Institutes (Taiwan)
Pai-Chi Li, National Taiwan Univ. (Taiwan)
Leu-Wei Lo, National Health Research Institutes (Taiwan)

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