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Journal of Biomedical Optics • Open Access

Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes
Author(s): Stephen C Kanick; Cor Van der Leest; Joachim Aerts; Henk C. Hoogsteden; Slávka Kascáková; Henricus J. C. M. Sterenborg; Arjen Amelink

Paper Abstract

We describe the incorporation of a single-fiber reflectance spectroscopy probe into the endoscopic ultrasound fine-needle aspiration (EUS-FNA) procedure utilized for lung cancer staging. A mathematical model is developed to extract information about the physiological and morphological properties of lymph tissue from single-fiber reflectance spectra, e.g., microvascular saturation, blood volume fraction, bilirubin concentration, average vessel diameter, and Mie slope. Model analysis of data from a clinical pilot study shows that the single-fiber reflectance measurement is capable of detecting differences in the physiology between normal and metastatic lymph nodes. Moreover, the clinical data show that probe manipulation within the lymph node can perturb the in vivo environment, a concern that must be carefully considered when developing a sampling strategy. The data show the feasibility of this novel technique; however, the potential clinical utility has yet to be determined.

Paper Details

Date Published: 1 January 2010
PDF: 8 pages
J. Biomed. Opt. 15(1) 017004 doi: 10.1117/1.3290822
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Stephen C Kanick, Erasmus MC (Netherlands)
Cor Van der Leest, Erasmus MC (Netherlands)
Joachim Aerts, Erasmus MC (Netherlands)
Henk C. Hoogsteden, Erasmus MC (Netherlands)
Slávka Kascáková, Erasmus MC (Netherlands)
Henricus J. C. M. Sterenborg, Erasmus MC (Netherlands)
Arjen Amelink, Erasmus MC (Netherlands)

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