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Journal of Biomedical Optics

Multistage inversion algorithm for biological tissue imaging
Author(s): Krishna Agarwal; Ling Chen; Nanguang Chen; Xudong Chen
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Paper Abstract

A new inversion method for diffuse optical tomography is proposed. This is a multistage algorithm, that uses a signal subspace-based method to simplify the inverse problem and proposes a guided iterative inversion process to improve the imaging. First, subspace-based analysis is used to determine the voxels that definitely belong to the background and exclude them from further consideration. Then, the pseudo-inverse technique is applied for reconstruction. In the final stage, the reconstruction is improved iteratively by finding and excluding more voxels belonging to background. The method reduces the ill-posedness of the image reconstruction problem iteratively such that good imaging results are obtained for multiple heterogeneities having complicated geometries even in the presence of 3% additive white noise.

Paper Details

Date Published: 1 January 2010
PDF: 7 pages
J. Biomed. Opt. 15(1) 016007 doi: 10.1117/1.3290809
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Krishna Agarwal, National Univ. of Singapore (Singapore)
Ling Chen, National Univ. of Singapore (Singapore)
Nanguang Chen, National Univ. of Singapore (Singapore)
Xudong Chen, National Univ. of Singapore (Singapore)


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