Share Email Print
cover

Journal of Biomedical Optics • Open Access

Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques
Author(s): Marcella A. Calfon; Claudio Vinegoni; Vasilis Ntziachristos; Farouc A. Jaffer

Paper Abstract

New imaging methods are urgently needed to identify high-risk atherosclerotic lesions prior to the onset of myocardial infarction, stroke, and ischemic limbs. Molecular imaging offers a new approach to visualize key biological features that characterize high-risk plaques associated with cardiovascular events. While substantial progress has been realized in clinical molecular imaging of plaques in larger arterial vessels (carotid, aorta, iliac), there remains a compelling, unmet need to develop molecular imaging strategies targeted to high-risk plaques in human coronary arteries. We present recent developments in intravascular near-IR fluorescence catheter-based strategies for in vivo detection of plaque inflammation in coronary-sized arteries. In particular, the biological, light transmission, imaging agent, and engineering principles that underlie a new intravascular near-IR fluorescence sensing method are discussed. Intravascular near-IR fluorescence catheters appear highly translatable to the cardiac catheterization laboratory, and thus may offer a new in vivo method to detect high-risk coronary plaques and to assess novel atherosclerosis biologics.

Paper Details

Date Published: 1 January 2010
PDF: 6 pages
J. Biomed. Opt. 15(1) 011107 doi: 10.1117/1.3280282
Published in: Journal of Biomedical Optics Volume 15, Issue 1
Show Author Affiliations
Marcella A. Calfon, Massachusetts General Hospital (United States)
Claudio Vinegoni, Massachusetts General Hospital (United States)
Vasilis Ntziachristos, Helmholtz Zentrum München GmbH (Germany)
Farouc A. Jaffer, Massachusetts General Hospital (United States)


© SPIE. Terms of Use
Back to Top