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Journal of Biomedical Optics • Open Access

Photonic approach to the selective inactivation of viruses with a near-infrared subpicosecond fiber laser
Author(s): Kong-Thon Tsen; Shaw-Wei David Tsen; Qiang Fu; Stuart M. Lindsay; Karen Kibler; Bert Jacobs; Tzyy Choou Wu; Balasubramanyam Karanam; Subhashini Jagu; Richard B. S. Roden; Chien-Fu Hung; Otto F. Sankey; B. Ramakrishna; Juliann G. Kiang

Paper Abstract

We report a photonic approach for selective inactivation of viruses with a near-infrared subpicosecond laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as the M13 bacteriophage and the tobacco mosaic virus to pathogenic viruses such as the human papillomavirus and the human immunodeficiency virus (HIV). At the same time, sensitive materials such as human Jurkat T cells, human red blood cells, and mouse dendritic cells remain unharmed. The laser technology targets the global mechanical properties of the viral protein shell, making it relatively insensitive to the local genetic mutation in the target viruses. As a result, the approach can inactivate both the wild and mutated strains of viruses. This intriguing advantage is particularly important in the treatment of diseases involving rapidly mutating viral species such as HIV. Our photonic approach could be used for the disinfection of viral pathogens in blood products and for the treatment of blood-borne viral diseases in the clinic.

Paper Details

Date Published: 1 November 2009
PDF: 7 pages
J. Biomed. Opt. 14(6) 064042 doi: 10.1117/1.3275477
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Kong-Thon Tsen, Arizona State Univ. (United States)
Shaw-Wei David Tsen, Washington Univ. in St. Louis School of Medicine (United States)
Qiang Fu, Arizona State Univ. (United States)
Stuart M. Lindsay, Arizona State Univ. (United States)
Karen Kibler, Arizona State Univ. (United States)
Bert Jacobs, Arizona State Univ. (United States)
Tzyy Choou Wu, The Johns Hopkins Univ. (United States)
Balasubramanyam Karanam, The Johns Hopkins Univ. (United States)
Subhashini Jagu, The Johns Hopkins Univ. (United States)
Richard B. S. Roden, The Johns Hopkins Univ. (United States)
Chien-Fu Hung, The Johns Hopkins Univ. (United States)
Otto F. Sankey, Arizona State Univ. (United States)
B. Ramakrishna, Arizona State Univ. (United States)
Juliann G. Kiang, Armed Forces Radiobiology Research Institute (United States)

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