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Journal of Biomedical Optics

Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study
Author(s): Elisabeth S. Papazoglou; Michael T. Neidrauer; Leonid Zubkov; Michael S. Weingarten; Kambiz Pourrezaei
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Paper Abstract

A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths (685 to 830 nm) to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a period ranging from 10 to 61 weeks. In all wounds that healed completely, gradual decreases in optical absorption coefficient, oxygenated hemoglobin concentration, and total hemoglobin concentration are observed between the first and last measurements. In nonhealing wounds, the rates of change of these properties are nearly zero or slightly positive, and a statistically significant difference (p<0.05) is observed in the rates of change between healing and nonhealing wounds. Differences in the variability of DPDW measurements over time are observed between healing and nonhealing wounds, and this variance may also be a useful indicator of nonhealing wounds. Our results demonstrate that DPDW methodology with a frequency domain NIR device can differentiate healing from nonhealing diabetic foot ulcers, and indicate that it may have clinical utility in the evaluation of wound healing potential.

Paper Details

Date Published: 1 November 2009
PDF: 10 pages
J. Biomed. Opt. 14(6) 064032 doi: 10.1117/1.3275467
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Elisabeth S. Papazoglou, Drexel Univ. (United States)
Michael T. Neidrauer, Drexel Univ. (United States)
Leonid Zubkov, Drexel Univ. (United States)
Michael S. Weingarten, Drexel Univ. College of Medicine (United States)
Kambiz Pourrezaei, Drexel Univ. (United States)

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