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Journal of Biomedical Optics • Open Access

Feasibility of Doppler variance imaging for red blood cell aggregation characterization
Author(s): Xiangqun Xu; Yeh-Chan Ahn; Zhongping Chen

Paper Abstract

An abnormal level of red blood cell (RBC) aggregation is a clinical condition associated with many pathologies. Our purpose is to investigate the feasibility of spectral domain phase-resolved optical Doppler tomography incorporated with Doppler variance imaging to characterize RBC aggregation in flowing blood. Variance/standard deviation (SD) of the Doppler frequency spectrum of porcine blood flowing through a glass tube (diameter 300 μm) at 4.7 mm/s is measured. For nonaggregating RBCs with hematocrits of 20, 40, and 60%, the mean centerline SD values were 34.2±1.2, 47.8±1.0, and 47.2±0.5, respectively. After dextran 500 induction, the SD value decreased significantly to 29.9±0.7, 37.9±3.0, and 40.1±0.6 (P<0.01) in the aggregated blood, respectively. The results demonstrate that Doppler variance imaging using the SD value is capable of differentiating normal and aggregated blood.

Paper Details

Date Published: 1 November 2009
PDF: 3 pages
J. Biomed. Opt. 14(6) 060507 doi: 10.1117/1.3275464
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Xiangqun Xu, Zhejiang Sci-Tech Univ. (China)
Yeh-Chan Ahn, Beckman Laser Institute and Medical Ctr. (United States)
Zhongping Chen, Beckman Laser Institute and Medical Ctr. (United States)


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