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Journal of Biomedical Optics

Multispecies breath analysis faster than a single respiratory cycle by optical-feedback cavity-enhanced absorption spectroscopy
Author(s): Irene Ventrillard-Courtillot; Thierry Gonthiez; Christine Clerici; Daniele Romanini
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Paper Abstract

We demonstrate a first application, of optical-feedback cavity-enhanced absorption spectroscopy (OF-CEAS) to breath analysis in a medical environment. Noninvasive monitoring of trace species in exhaled air was performed simultaneous to spirometric measurements on patients at Bichat Hospital (Paris). The high selectivity of the OF-CEAS spectrometer and a time response of 0.3 s (limited by sample flow rate) allowed following the evolution of carbon monoxide and methane concentrations during individual respiratory cycles, and resolving variations among different ventilatory patterns. The minimum detectable absorption on this time scale is about 3×10-10 cm-1. At the working wavelength of the instrument (2.326 μm), this translates to concentration detection limits of ~1 ppbv (45 picomolar, or ~1.25 μg/m3) for CO and 25 ppbv for CH4, well below concentration values found in exhaled air. This same instrument is also able to provide measurement of NH3 concentrations with a detection limit of ~10 ppbv; however, at present, memory effects do not allow its measurement on fast time scales.

Paper Details

Date Published: 1 November 2009
PDF: 5 pages
J. Biomed. Opt. 14(6) 064026 doi: 10.1117/1.3269677
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Irene Ventrillard-Courtillot, Univ. Joseph Fourier (France)
Thierry Gonthiez, Floralis (France)
Christine Clerici, Hôpital Bichat-Claude Bernard (France)
Daniele Romanini, Univ. Joseph Fourier (France)

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