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Journal of Biomedical Optics • Open Access

Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection
Author(s): Andrzej May; Srabani Bhaumik; Sanjiv Sam Gambhir; Chun Zhan; Siavash Yazdanfar

Paper Abstract

We describe a wide-field preclinical imaging system optimized for time-gated detection of quantum dot fluorescence emission. As compared to continuous wave measurements, image contrast was substantially improved by suppression of short-lifetime background autofluorescence. Real-time (8 frames/s) biological imaging of subcutaneous quantum dot injections is demonstrated simultaneously in multiple living mice.

Paper Details

PDF: 3 pages
J. Biomed. Opt. 14(6) 060504 doi: 10.1117/1.326967
Published in: Journal of Biomedical Optics Volume 14, Issue 6, November 2009
Show Author Affiliations
Andrzej May, GE Global Research (United States)
Srabani Bhaumik, GE Global Research (United States)
Sanjiv Sam Gambhir, Stanford Univ. (United States)
Chun Zhan, GE Global Research (United States)
Siavash Yazdanfar, GE Global Research (United States)

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