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Journal of Biomedical Optics • Open Access

In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography
Author(s): Jiechen Yin; Gangjun Liu; Jun Zhang; Lingfeng Yu; Sari B. Mahon; David Sho Mukai; Matthew Brenner; Zhongping Chen

Paper Abstract

We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based on the comprehensive 3-D volumetric data.

Paper Details

Date Published: 1 November 2009
PDF: 3 pages
J. Biomed. Opt. 14(6) 060503 doi: 10.1117/1.3268775
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Jiechen Yin, Univ. of California, Irvine (United States)
Gangjun Liu, Beckman Laser Institute and Medical Ctr. (United States)
Jun Zhang, Beckman Laser Institute and Medical Ctr. (United States)
Lingfeng Yu, Beckman Laser Institute and Medical Ctr. (United States)
Sari B. Mahon, Beckman Laser Institute and Medical Ctr. (United States)
David Sho Mukai, Beckman Laser Institute and Medical Ctr. (United States)
Matthew Brenner, Univ. of California, Irvine (United States)
Zhongping Chen, Beckman Laser Institute and Medical Ctr. (United States)


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