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Journal of Biomedical Optics

Whole-body three-dimensional optoacoustic tomography system for small animals
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Paper Abstract

We develop a system for three-dimensional whole-body optoacoustic tomography of small animals for applications in preclinical research. The tomographic images are obtained while the objects of study (phantoms or mice) are rotated within a sphere outlined by a concave arc-shaped array of 64 piezocomposite transducers. Two pulsed lasers operating in the near-IR spectral range (755 and 1064 nm) with an average pulsed energy of about 100 mJ, a repetition rate of 10 Hz, and a pulse duration of 15 to 75 ns are used as optical illumination sources. During the scan, the mouse is illuminated orthogonally to the array with two wide beams of light from a bifurcated fiber bundle. The system is capable of generating images of individual organs and blood vessels through the entire body of a mouse with spatial resolution of ~0.5 mm.

Paper Details

Date Published: 1 November 2009
PDF: 8 pages
J. Biomed. Opt. 14(6) 064007 doi: 10.1117/1.3259361
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Hans-Peter F. Brecht, Fairway Medical Technologies, Inc. (United States)
Richard Su, Fairway Medical Technologies, Inc. (United States)
Matthew P. Fronheiser, Seno Medical Instruments, Inc. (United States)
Sergey A. Ermilov, Fairway Medical Technologies, Inc. (United States)
André Conjusteau, Fairway Medical Technologies, Inc. (United States)
Alexander A. Oraevsky, Fairway Medical Technologies, Inc. (United States)

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