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Journal of Biomedical Optics

Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study
Author(s): Yao Sun; Eric S. Sobel; Huabei Jiang
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Paper Abstract

We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The results show that major anatomical features in the joint along with the side arteries can be imaged with a 1-MHz transducer in a spherical scanning geometry. In addition, the cartilages associated with the joint can be quantitatively differentiated from the phalanx. This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis.

Paper Details

Date Published: 1 November 2009
PDF: 5 pages
J. Biomed. Opt. 14(6) 064002 doi: 10.1117/1.3257246
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Yao Sun, Univ. of Florida (United States)
Eric S. Sobel, Univ. of Florida (United States)
Huabei Jiang, Univ. of Florida (United States)

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