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Journal of Biomedical Optics • Open Access

Bimodal ultrasound and fluorescence approach for prostate cancer diagnosis
Author(s): Jerome Boutet; Lionel Hervé; Mathieu Debourdeau; Laurent Guyon; Philippe Peltie; Jean-Marc Dinten; Laurent Saroul; Francois Duboeuf; Didier Vray

Paper Abstract

Finding a way to combine ultrasound and fluorescence optical imaging on an endorectal probe may improve early detection of prostate cancer. The ultrasound provides morphological information about the prostate, while the optical system detects and locates fluorophore-marked tumors. A tissue-mimicking phantom, which is representative of prostate tissues both on its optical (absorption µa and diffusion µ) and its ultrasound properties, has been made by our team. A transrectal probe adapted to fluorescence diffuse optical tomography measurements was also developed. Measurements were taken on the prostate phantom with this probe based on a pulsed laser and a time-resolved detection system. A reconstruction algorithm was then used to help locate and quantify fluorescent inclusions of different concentrations at fixed depths.

Paper Details

Date Published: 1 November 2009
PDF: 7 pages
J. Biomed. Opt. 14(6) 064001 doi: 10.1117/1.3257236
Published in: Journal of Biomedical Optics Volume 14, Issue 6
Show Author Affiliations
Jerome Boutet, Commissariat à l'Énergie Atomique (France)
Lionel Hervé, Commissariat à l'Énergie Atomique (France)
Mathieu Debourdeau, Commissariat à l'Énergie Atomique (France)
Laurent Guyon, Commissariat à l'Énergie Atomique (France)
Philippe Peltie, Commissariat à l'Énergie Atomique (France)
Jean-Marc Dinten, Commissariat à l'Énergie Atomique (France)
Laurent Saroul, Probayes SAS (France)
Francois Duboeuf, CREATIS-LRMN INSA (France)
Didier Vray, CREATIS-LRMN INSA (France)

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