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Journal of Biomedical Optics

Diffuse optical spectroscopy of breast tissue extended to 1100 nm
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Paper Abstract

The feasibility of in vivo measurements in the range of 1000 to 1100 nm and the potential benefits of operation in that wavelength range for diagnostic applications are investigated. To this purpose, an existing system for time-resolved diffuse spectroscopy is modified to enable in vivo studies to be carried out continuously from 600 to 1100 nm. The optical characterization of collagen powder is extended to 1100 nm and an accurate measurement of the absorption properties of lipid is carried out over the entire spectral range. Finally, the first in vivo absorption and scattering spectra of breast tissue are measured from 10 healthy volunteers between 600 and 1100 nm and tissue composition is evaluated in terms of blood parameters and water, lipid, and collagen content using a spectrally constrained global fitting procedure.

Paper Details

Date Published: 1 September 2009
PDF: 7 pages
J. Biomed. Opt. 14(5) 054030 doi: 10.1117/1.3251051
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Paola Taroni, Politecnico di Milano (Italy)
Andrea Bassi, Politecnico di Milano (Italy)
Daniela Comelli, Politecnico di Milano (Italy)
Andrea Farina, Politecnico di Milano (Italy)
Rinaldo Cubeddu, Politecnico di Milano (Italy)
Antonio Pifferi, Politecnico di Milano (Italy)

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