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Journal of Biomedical Optics

Depth-resolved measurement of ocular fundus pulsations by low-coherence tissue interferometry
Author(s): Nikolaus Dragostinoff; René Werkmeister; Martin Gröschl; Leopold F. Schmetterer
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Paper Abstract

A device that allows for the measurement of ocular fundus pulsations at preselected axial positions of a subject's eye is presented. Unlike previously presented systems, which only allow for observation of the strongest reflecting retinal layer, our system enables the measurement of fundus pulsations at a preselected ocular layer. For this purpose the sample is illuminated by light of low temporal coherence. The layer is then selected by positioning one mirror of a Michelson interferometer according to the depth of the layer. The device contains a length measurement system based on partial coherence interferometry and a line scan charge-coupled device camera for recording and online inspection of the fringe system. In-vivo measurements in healthy humans are performed as proof of principle. The algorithms used for enhancing the recorded images are briefly introduced. The contrast of the observed interference pattern is evaluated for different positions of the measurement mirror and at various distances from the front surface of the cornea. The applications of such a system may be wide, including assessment of eye elongation during myopia development and blood-flow-related changes in intraocular volume.

Paper Details

Date Published: 1 September 2009
PDF: 9 pages
J. Biomed. Opt. 14(5) 054047 doi: 10.1117/1.3251049
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Nikolaus Dragostinoff, Medizinische Univ. Wien (Austria)
René Werkmeister, Medizinische Univ. Wien (Austria)
Martin Gröschl, Technische Univ. Wien (Austria)
Leopold F. Schmetterer, Medizinische Univ. Wien (Austria)

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