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Journal of Biomedical Optics

Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts
Author(s): Karthik Vishwanath; Daniel Hunter Klein; Kevin Chang; Thies Schroeder; Mark W. Dewhirst; Nirmala Ramanujam
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Paper Abstract

Noninvasive and longitudinal monitoring of tumor oxygenation status using quantitative diffuse reflectance spectroscopy is used to test whether a final treatment outcome could be estimated from early optical signatures in a murine model of head and neck cancer when treated with radiation. Implanted tumors in the flank of 23 nude mice are exposed to 39 Gy of radiation, while 11 animals exposed to sham irradiation serve as controls. Diffuse optical reflectance is measured from the tumors at baseline (prior to irradiation) and then serially until 17 days posttreatment. The fastest and greatest increase in baseline-corrected blood oxygen saturation levels are observed from the animals that show complete tumor regression with no recurrence 90 days postirradiation, relative to both untreated and treated animals with local recurrences. These increases in saturation are observed starting 5 days posttreatment and last up to 17 days posttreatment. This preclinical study demonstrates that diffuse reflectance spectroscopy could provide a practical method far more effective than the growth delay assay to prognosticate treatment outcome in solid tumors and may hold significant translational promise.

Paper Details

Date Published: 1 September 2009
PDF: 4 pages
J. Biomed. Opt. 14(5) 054051 doi: 10.1117/1.3251013
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Karthik Vishwanath, Duke Univ. (United States)
Daniel Hunter Klein, Duke Univ. (United States)
Kevin Chang, Duke Univ. (United States)
Thies Schroeder, Duke Univ. (United States)
Mark W. Dewhirst, Duke Univ. (United States)
Nirmala Ramanujam, Duke Univ. (United States)


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