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Journal of Biomedical Optics

Risk assessment of the application of a plasma jet in dermatology
Author(s): Jürgen M. Lademann; Heike Richter; Alena Alborova; D. Humme; Alexa Patzelt; Axel Kramer; K. D. Weltmann; B. Hartmann; C. Ottomann; J. W. Fluhr; P. Hinz; G. Hübner; O. Lademann
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Paper Abstract

Regardless of the fact that several highly efficient antiseptics are commercially available, the antiseptic treatment of chronic wounds remains a problem. In the past, electrical plasma discharges have been frequently used in biometrical science for disinfection and sterilization of material surfaces. Plasma systems usually have a temperature of several hundred degrees. Recently, it was reported that "cold" plasma can be applied onto living tissue. In in vitro studies on cell culture, it could be demonstrated that this new plasma possesses excellent antiseptic properties. We perform a risk assessment concerning the in vivo application of a "cold" plasma jet on patients and volunteers. Two potential risk factors, UV radiation and temperature, are evaluated. We show that the UV radiation of the plasma in the used system is an order of magnitude lower than the minimal erythema dose, necessary to produce sunburn on the skin in vivo. Additionally, thermal damage of the tissue by the plasma can be excluded. The results of the risk assessment stimulate the in vivo application of the investigated plasma jet in the treatment of chronic wounds.

Paper Details

Date Published: 1 September 2009
PDF: 6 pages
J. Biomed. Opt. 14(5) 054025 doi: 10.1117/1.3247156
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Jürgen M. Lademann, Charité Universitätsmedizin Berlin (Germany)
Heike Richter, Charité Universitätsmedizin Berlin (Germany)
Alena Alborova, Charité Universitätsmedizin Berlin (Germany)
D. Humme, Charité Universitätsmedizin Berlin (Germany)
Alexa Patzelt, Charité Universitätsmedizin Berlin (Germany)
Axel Kramer, Ernst Moritz Arndt Univ. Greifswald (Germany)
K. D. Weltmann, INP Greifswald e.V. (Germany)
B. Hartmann, Unfallkrankenhaus Berlin (UKB) (Germany)
C. Ottomann, Unfallkrankenhaus Berlin (UKB) (Germany)
J. W. Fluhr, Charité Universitätsmedizin Berlin (Germany)
P. Hinz, Ernst Moritz Arndt Univ. Greifswald (Germany)
G. Hübner, Ernst Moritz Arndt Univ. Greifswald (Germany)
O. Lademann, Ernst Moritz Arndt Univ. Greifswald (Germany)

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