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Journal of Biomedical Optics

Investigation of the prefrontal cortex in response to duration-variable anagram tasks using functional near-infrared spectroscopy
Author(s): Fenghua Tian; Britton Chance; Hanli Liu
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Paper Abstract

We hypothesize that nonlinearity between short-term anagram tasks and corresponding hemodynamic responses can be observed by functional near-infrared spectroscopy (fNIRS) in the prefrontal cortex (PFC). The PFC of six human subjects in response to anagram tasks is investigated using multichannel fNIRS. Concentration changes of oxyhemoglobin and deoxyhemoglobin in the PFC are measured with variable anagram durations and at two difficulty levels (four- and six-letter anagrams). The durations to perform the selected anagram tasks range from several seconds to more than one minute. The dorsolateral PFC areas exhibit consistent and strong hemodynamic deactivation during and shortly after task execution. The superposition principle of a linear system is employed to investigate nonlinear hemodynamic features among three task duration subgroups: D1 = 2.0 sec, D2 = 4.0 sec, and D3 = 8.0 sec. Such analysis shows clear nonlinearity in hemodynamic responses on the PFC with task durations shorter than 4 sec. Our observation of significant deactivation in early hemodynamic responses in the PFC is consistent with multiple fNIRS studies and several reports given in the field of functional magnetic resonance imaging. A better understanding of nonlinearity in fNIRS signals will have potential for us to investigate brain adaptation and to extrapolate neuronal activities from hemodynamic signals.

Paper Details

Date Published: 1 September 2009
PDF: 11 pages
J. Biomed. Opt. 14(5) 054016 doi: 10.1117/1.3241984
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Fenghua Tian, The Univ. of Texas at Arlington (United States)
Britton Chance, Univ. of Pennsylvania (United States)
Hanli Liu, The Univ. of Texas at Arlington (United States)

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