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Journal of Biomedical Optics

Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization
Author(s): Andres Aguirre; Puyun Guo; John K. Gamelin; Shikui Yan; Mary M. Sanders; Molly A. Brewer; Quing Zhu
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Paper Abstract

Ovarian cancer has the highest mortality of all gynecologic cancers, with a five-year survival rate of only 30% or less. Current imaging techniques are limited in sensitivity and specificity in detecting early stage ovarian cancer prior to its widespread metastasis. New imaging techniques that can provide functional and molecular contrasts are needed to reduce the high mortality of this disease. One such promising technique is photoacoustic imaging. We develop a 1280-element coregistered 3-D ultrasound and photoacoustic imaging system based on a 1.75-D acoustic array. Volumetric images over a scan range of 80 deg in azimuth and 20 deg in elevation can be achieved in minutes. The system has been used to image normal porcine ovarian tissue. This is an important step toward better understanding of ovarian cancer optical properties obtained with photoacoustic techniques. To the best of our knowledge, such data are not available in the literature. We present characterization measurements of the system and compare coregistered ultrasound and photoacoustic images of ovarian tissue to histological images. The results show excellent coregistration of ultrasound and photoacoustic images. Strong optical absorption from vasculature, especially highly vascularized corpora lutea and low absorption from follicles, is demonstrated.

Paper Details

Date Published: 1 September 2009
PDF: 9 pages
J. Biomed. Opt. 14(5) 054014 doi: 10.1117/1.3233916
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Andres Aguirre, Univ. of Connecticut (United States)
Puyun Guo, ElectroCore, LLC (United States)
John K. Gamelin, Univ. of Connecticut (United States)
Shikui Yan, Univ. of Connecticut (United States)
Mary M. Sanders, Univ. of Connecticut Health Ctr. (United States)
Molly A. Brewer, The Univ. of Arizona (United States)
Quing Zhu, Univ. of Connecticut (United States)


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