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Journal of Biomedical Optics

Diagnosis of oral submucous fibrosis with optical coherence tomography
Author(s): Cheng-Kuang Lee; Meng-Tsan Tsai; Hsiang-Chieh Lee; Hsin-Ming Chen; Chun-Ping Chiang; Yih-Ming Wang; Chih-Chung Yang
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Paper Abstract

The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of ~6 µm in axial resolution (in tissue) and 103 dB in sensitivity. Compared with the corresponding parameters in healthy oral mucosal mucosa, in OSF mucosa, the EP thickness becomes smaller and the SD of A-mode scan intensity in the LP layer (LP SD) also becomes smaller. The LP SD can also be used for effectively differentiating OSF (small LP SD) from lesion (large LP SD). This application is particularly useful in the case of a lesion without a clear surface feature. Meanwhile, the use of the SD of A-mode scan intensity in the EP layer (EP SD) can further help in differentiating OSF (medium EP SD) from healthy oral mucosal (small EP SD) and lesion (large EP SD) conditions. Compared with the conventional method of maximum mouth opening measurement, the use of the proposed OCT scanning results can be a more effective technique for OSF diagnosis.

Paper Details

Date Published: 1 September 2009
PDF: 7 pages
J. Biomed. Opt. 14(5) 054008 doi: 10.1117/1.3233653
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Cheng-Kuang Lee, National Taiwan Univ. (Taiwan)
Meng-Tsan Tsai, National Taiwan Univ. (Taiwan)
Hsiang-Chieh Lee, National Taiwan Univ. (Taiwan)
Hsin-Ming Chen, National Taiwan Univ. (Taiwan)
Chun-Ping Chiang, National Taiwan Univ. (Taiwan)
Yih-Ming Wang, National Taiwan Univ. (Taiwan)
Chih-Chung Yang, National Taiwan Univ. (Taiwan)

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