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Journal of Biomedical Optics • Open Access

Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds
Author(s): Joseph Chaiken; Jerry Goodisman; Bin Deng; Rebecca Jane Bussjaeger; George Shaheen

Paper Abstract

We report simultaneous observation of elastic scattering, fluorescence, and inelastic scattering from in vivo near-infrared probing of human skin. Careful control of the mechanical force needed to obtain reliable registration of in vivo tissue with an appropriate optical system allows reproducible observation of blood flow in capillary beds of human volar side fingertips. The time dependence of the elastically scattered light is highly correlated with that of the combined fluorescence and Raman scattered light. We interpret this in terms of turbidity (the impeding effect of red blood cells on optical propagation to and from the scattering centers) and the changes in the volume percentages of the tissues in the irradiated volume with normal homeostatic processes. By fitting to a model, these measurements may be used to determine volume fractions of plasma and RBCs.

Paper Details

Date Published: 1 September 2009
PDF: 3 pages
J. Biomed. Opt. 14(5) 050505 doi: 10.1117/1.3233629
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Joseph Chaiken, Syracuse Univ. (United States)
Jerry Goodisman, Syracuse Univ. (United States)
Bin Deng, Syracuse Univ. (United States)
Rebecca Jane Bussjaeger, Air Force Research Lab. (United States)
George Shaheen, LighTouch Medical, Inc. (United States)

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