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Journal of Biomedical Optics • Open Access

Doppler optical microangiography improves the quantification of local fluid flow and shear stress within 3-D porous constructs
Author(s): Yali Jia; Lin An; Ruikang K. Wang

Paper Abstract

Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) with a phase-resolved method, for improved assessment of local fluid flow and its derived parameters, shear stress, and interconnectivity, within highly scattering porous constructs. Compared with DOCT, we demonstrate a dramatic improvement of DOMAG in quantifying flow-related properties within scaffolds in situ for functional tissue engineering.

Paper Details

Date Published: 1 September 2009
PDF: 3 pages
J. Biomed. Opt. 14(5) 050504 doi: 10.1117/1.3233590
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Yali Jia, Oregon Health & Science Univ. (United States)
Lin An, Oregon Health & Science Univ. (United States)
Ruikang K. Wang, Oregon Health & Science Univ. (United States)

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