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Journal of Biomedical Optics

Photoacoustic tomography of small animal brain with a curved array transducer
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Paper Abstract

We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ~1 frame/second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15 s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging.

Paper Details

Date Published: 1 September 2009
PDF: 5 pages
J. Biomed. Opt. 14(5) 054007 doi: 10.1117/1.3227035
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Xinmai Yang, The Univ. of Kansas (United States)
Anastasios Maurudis, Univ. of Connecticut (United States)
John K. Gamelin, Univ. of Connecticut (United States)
Andres Aguirre, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)
Lihong V. Wang, Washington Univ. in St. Louis (United States)


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