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Journal of Biomedical Optics • Open Access

Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel
Author(s): Shuaixia Tan; Hongjun Dai; Juejie Wu; Ning Zhao; Xiaoli Zhang; Jian Xu

Paper Abstract

Real-time electronic speckle pattern interferometry method has been applied to study the diffusion behavior of levofloxacin mesylate (MSALVFX) in agarose hydrogel. The results show that the diffusivity of solute decreases with the increase of concentration of agarose and adapts to Kohlrausch's law. Furthermore, Amsden's model, based on the retardance effect associated with polymer chain flexibility, was employed to simulate the diffusion behavior. The consistent results suggest that the retardance effect dominates the diffusion process of MSALFVX in hydrogel; moreover, polymer chain flexibility greatly affects drug transport within the polymer matrix.

Paper Details

Date Published: 1 September 2009
PDF: 3 pages
J. Biomed. Opt. 14(5) 050503 doi: 10.1117/1.3227034
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Shuaixia Tan, Institute of Chemistry (China)
Hongjun Dai, Institute of Chemistry (China)
Juejie Wu, Institute of Chemistry (China)
Ning Zhao, Institute of Chemistry (China)
Xiaoli Zhang, Institute of Chemistry (China)
Jian Xu, Institute of Chemistry (China)

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