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Journal of Biomedical Optics • Open Access

On the possibility of time-lapse ultrahigh-resolution optical coherence tomography for bladder cancer grading
Author(s): Zhijia Yuan; Bai Chen; H. G. Ren; Yingtian Pan

Paper Abstract

It has been recently demonstrated that the cellular details of bladder epithelium embedded in speckle noise can be uncovered with time-lapse ultrahigh-resolution optical coherence tomography (TL-uOCT) by proper time-lapse frame averaging that takes advantage of cellular micromotion in fresh biological tissue ex vivo. Here, spectral-domain 3-D TL-uOCT is reported to further improve the image fidelity, and new experimental evidence is presented to differentiate normal and cancerous nuclei of rodent bladder epithelia. Results of animal cancer study reveal that despite a slight overestimation (e.g., <10%) of nuclear size (DN) to histological evaluation, TL-uOCT is capable of distinguishing normal (DN7 ≈ μm) and cancerous (e.g., high-grade DN″13 μm) urothelia, which may potentially be very useful for enhancing the diagnosis of nonpapillary bladder cancer. More animal study is being conducted to examine the utility to differentiate hyperplasia, dysplasia, and carcinoma in situ.

Paper Details

Date Published: 1 September 2009
PDF: 3 pages
J. Biomed. Opt. 14(5) 050502 doi: 10.1117/1.3223246
Published in: Journal of Biomedical Optics Volume 14, Issue 5
Show Author Affiliations
Zhijia Yuan, Stony Brook Univ. (United States)
Bai Chen, Stony Brook Univ. (United States)
H. G. Ren, Stony Brook Univ. (United States)
Yingtian Pan, Stony Brook Univ. (United States)

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